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EMD-25176

Single-particle
3.3 Å
EMD-25176
3D View Gallery
Deposition: 19/10/2021
Map released: 27/07/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25176
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7sk8 summary report (pdf.gz) Map and 7sk8 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab

EMD-25176

Single-particle
3.3 Å
EMD-25176
3D View Gallery
Deposition: 19/10/2021
Map released: 27/07/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex structure of CID25-ACKR3-CXCL12-CCX662-CID24
Fitted models: 7sk8

Deposition Authors: Yen YC , Schafer CT , Gustavsson M , Handel TM , Tesmer JJG
Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Yen YC , Schafer CT , Gustavsson M , Eberle SA , Dominik PK, Deneka D , Zhang P , Schall TJ, Kossiakoff AA, Tesmer JJG , Handel TM
(2022) Sci Adv , 8 , eabn8063 - eabn8063
PUBMED: 35857509
DOI: doi:10.1126/sciadv.abn8063
ISSN: 2375-2548