EMD-25173
Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab
EMD-25173
Single-particle4.0 Å
Deposition: 19/10/2021Map released: 27/07/2022
Last modified: 04/06/2025
Sample Organism:
Homo sapiens,
Lama glama
Sample: Complex structure of ACKR3-CXCL12-CID24-NB
Fitted models: 7sk5
Deposition Authors: Yen YC
,
Schafer CT ,
Gustavsson M ,
Handel TM ,
Tesmer JJG
Sample: Complex structure of ACKR3-CXCL12-CID24-NB
Fitted models: 7sk5
Deposition Authors: Yen YC
,
Schafer CT ,
Gustavsson M ,
Handel TM ,
Tesmer JJG
Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Yen YC ,
Schafer CT ,
Gustavsson M ,
Eberle SA ,
Dominik PK,
Deneka D ,
Zhang P ,
Schall TJ,
Kossiakoff AA,
Tesmer JJG ,
Handel TM
(2022) Sci Adv , 8 , eabn8063 - eabn8063
,
Schafer CT ,
Gustavsson M ,
Eberle SA ,
Dominik PK,
Deneka D ,
Zhang P ,
Schall TJ,
Kossiakoff AA,
Tesmer JJG ,
Handel TM
(2022) Sci Adv , 8 , eabn8063 - eabn8063
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA254402 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI161880 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA221289 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL071818 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA023168 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM137505 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM117372 (United States)