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EMD-25105
Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
EMD-25105
Single-particle3.43 Å
Deposition: 04/10/2021Map released: 10/11/2021
Last modified: 23/10/2024
Sample Organism:
Severe acute respiratory syndrome coronavirus,
Homo sapiens
Sample: SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
Fitted models: 7sg4
Deposition Authors: Gobeil S
,
Acharya P
Sample: SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
Fitted models: 7sg4
Deposition Authors: Gobeil S
,
Acharya P
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.
Martinez DR ,
Schafer A ,
Gobeil S ,
Li D,
De la Cruz G ,
Parks R ,
Lu X ,
Barr M,
Stalls V ,
Janowska K,
Beaudoin E ,
Manne K ,
Mansouri K,
Edwards RJ ,
Cronin K ,
Yount B,
Anasti K ,
Montgomery SA ,
Tang J,
Golding H,
Shen S,
Zhou T ,
Kwong PD ,
Graham BS ,
Mascola JR ,
Montefiori DC ,
Alam SM,
Sempowski G,
Sempowski GD ,
Khurana S ,
Wiehe K ,
Saunders KO ,
Acharya P ,
Haynes BF ,
Baric RS
(2022) Sci Transl Med , 14 , eabj7125 - eabj7125
,
Schafer A ,
Gobeil S ,
Li D,
De la Cruz G ,
Parks R ,
Lu X ,
Barr M,
Stalls V ,
Janowska K,
Beaudoin E ,
Manne K ,
Mansouri K,
Edwards RJ ,
Cronin K ,
Yount B,
Anasti K ,
Montgomery SA ,
Tang J,
Golding H,
Shen S,
Zhou T ,
Kwong PD ,
Graham BS ,
Mascola JR ,
Montefiori DC ,
Alam SM,
Sempowski G,
Sempowski GD ,
Khurana S ,
Wiehe K ,
Saunders KO ,
Acharya P ,
Haynes BF ,
Baric RS
(2022) Sci Transl Med , 14 , eabj7125 - eabj7125
Grant Support: