Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-25100
Unmethylated Mtb Ribosome 50S with SEQ-9
EMD-25100
Single-particle2.6 Å
Deposition: 04/10/2021Map released: 12/10/2022
Last modified: 05/06/2024
Sample Organism:
Mycobacterium tuberculosis
Sample: Unmethylated Mth Ribosome with SEQ-9
Fitted models: 7sfr
Deposition Authors: Xing Z, Cui Z
Sample: Unmethylated Mth Ribosome with SEQ-9
Fitted models: 7sfr
Deposition Authors: Xing Z, Cui Z
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Zhang J,
Lair C,
Roubert C,
Amaning K,
Barrio MB ,
Benedetti Y,
Cui Z ,
Xing Z,
Li X,
Franzblau SG ,
Baurin N,
Bordon-Pallier F,
Cantalloube C,
Sans S,
Silve S,
Blanc I,
Fraisse L,
Rak A ,
Jenner LB,
Yusupova G,
Yusupov M,
Zhang J,
Kaneko T,
Yang TJ,
Fotouhi N,
Nuermberger E,
Tyagi S,
Betoudji F,
Upton A,
Sacchettini JC,
Lagrange S
(2023) Cell , 186 , 1013
,
Benedetti Y,
Cui Z ,
Xing Z,
Li X,
Franzblau SG ,
Baurin N,
Bordon-Pallier F,
Cantalloube C,
Sans S,
Silve S,
Blanc I,
Fraisse L,
Rak A ,
Jenner LB,
Yusupova G,
Yusupov M,
Zhang J,
Kaneko T,
Yang TJ,
Fotouhi N,
Nuermberger E,
Tyagi S,
Betoudji F,
Upton A,
Sacchettini JC,
Lagrange S
(2023) Cell , 186 , 1013
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): P01AI095208 (United States)
- Welch Foundation: A1863 (United States)