EMD-24899

Single-particle
2.58 Å
EMD-24899
3D View Gallery
Deposition: 18/09/2021
Map released: 17/11/2021
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-24899

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7s8o summary report (pdf.gz) Map-7s8o FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of Gi-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573

EMD-24899

Single-particle
2.58 Å
EMD-24899
3D View Gallery
Deposition: 18/09/2021
Map released: 17/11/2021
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: MRGPRX2-Gi1 (R)-ZINC-3573
Fitted models: 7s8o

Deposition Authors: Cao C , Fay JF
Structure, function and pharmacology of human itch GPCRs.
Cao C , Kang HJ , Singh I, Chen H , Zhang C, Ye W , Hayes BW , Liu J , Gumpper RH, Bender BJ, Slocum ST, Krumm BE , Lansu K, McCorvy JD , Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S , Liu Y , Kim K, Karpiak J, Jan LY , Abraham SN, Jin J , Shoichet BK , Fay JF , Roth BL
(2021) Nature , 600 , 170 - 175
PUBMED: 34789874
DOI: doi:10.1038/s41586-021-04126-6
ISSN: 1476-4687
ASTM: NATUAS