EMD-24812

Single-particle
3.6 Å
EMD-24812
3D View Gallery
Deposition: 02/09/2021
Map released: 25/05/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-24812

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7s1y summary report (pdf.gz) Map-7s1y FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide

EMD-24812

Single-particle
3.6 Å
EMD-24812
3D View Gallery
Deposition: 02/09/2021
Map released: 25/05/2022
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: hNKCC1 K289NA492E bound with bumetanide
Fitted models: 7s1y

Deposition Authors: Zhao YX, Cao E
Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Zhao Y, Roy K, Vidossich P, Cancedda L, De Vivo M, Forbush B, Cao E
(2022) Nat Commun , 13 , 2747
DOI: doi:10.1038/s41467-022-30407-3
ISSN: 2041-1723
Grant Support: