EMD-24794

Single-particle
3.8 Å
EMD-24794
3D View Gallery
Deposition: 01/09/2021
Map released: 08/06/2022
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-24794

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7s15 summary report (pdf.gz) Map-7s15 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

GLP-1 receptor bound with Pfizer small molecule agonist

EMD-24794

Single-particle
3.8 Å
EMD-24794
3D View Gallery
Deposition: 01/09/2021
Map released: 08/06/2022
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: agonist bound GLP1 receptor
Fitted models: 7s15

Deposition Authors: Liu Y, Dias JM
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Griffith DA , Edmonds DJ, Fortin JP, Kalgutkar AS , Kuzmiski JB, Loria PM, Saxena AR, Bagley SW , Buckeridge C, Curto JM, Derksen DR, Dias JM, Griffor MC, Han S, Jackson VM, Landis MS, Lettiere D, Limberakis C , Liu Y, Mathiowetz AM, Patel JC, Piotrowski DW , Price DA, Ruggeri RB , Tess DA
(2022) J Med Chem , 65 , 8208 - 8226
PUBMED: 35647711
DOI: doi:10.1021/acs.jmedchem.1c01856
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: