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EMD-24453
cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide
EMD-24453
Single-particle2.9 Å
Deposition: 15/07/2021Map released: 13/04/2022
Last modified: 13/04/2022
Sample Organism:
Homo sapiens,
Mus musculus,
Lama glama
Sample: cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide, trimeric G protein complex and stabilizing antibodies
Fitted models: 7rgp
Deposition Authors: Sun B
,
Kobilka BK ,
Sloop KW ,
Feng D ,
Kobilka TS
Sample: cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide, trimeric G protein complex and stabilizing antibodies
Fitted models: 7rgp
Deposition Authors: Sun B
,
Kobilka BK ,
Sloop KW ,
Feng D ,
Kobilka TS
Structural determinants of dual incretin receptor agonism by tirzepatide.
Sun B ,
Willard FS,
Feng D ,
Alsina-Fernandez J,
Chen Q ,
Vieth M,
Ho JD,
Showalter AD,
Stutsman C,
Ding L,
Suter TM,
Dunbar JD,
Carpenter JW,
Mohammed FA ,
Aihara E,
Brown RA ,
Bueno AB ,
Emmerson PJ,
Moyers JS ,
Kobilka TS,
Coghlan MP ,
Kobilka BK ,
Sloop KW
(2022) PNAS , 119 , e2116506119 - e2116506119
,
Willard FS,
Feng D ,
Alsina-Fernandez J,
Chen Q ,
Vieth M,
Ho JD,
Showalter AD,
Stutsman C,
Ding L,
Suter TM,
Dunbar JD,
Carpenter JW,
Mohammed FA ,
Aihara E,
Brown RA ,
Bueno AB ,
Emmerson PJ,
Moyers JS ,
Kobilka TS,
Coghlan MP ,
Kobilka BK ,
Sloop KW
(2022) PNAS , 119 , e2116506119 - e2116506119
Grant Support:
- Other private: (United States)