EMD-24401

Single-particle
3.08 Å
EMD-24401
3D View Gallery
Deposition: 06/07/2021
Map released: 13/04/2022
Last modified: 04/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-24401

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7rbt summary report (pdf.gz) Map-7rbt FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide

EMD-24401

Single-particle
3.08 Å
EMD-24401
3D View Gallery
Deposition: 06/07/2021
Map released: 13/04/2022
Last modified: 04/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus, Lama glama
Sample: cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to Tirzepatide, trimeric G protein complex and stabilizing antibodies
Fitted models: 7rbt

Deposition Authors: Sun B, Kobilka BK
Structural determinants of dual incretin receptor agonism by tirzepatide.
Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q , Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA , Aihara E, Brown RA , Bueno AB , Emmerson PJ, Moyers JS , Kobilka TS, Coghlan MP , Kobilka BK , Sloop KW
(2022) PNAS , 119 , e2116506119 - e2116506119
PUBMED: 35333651
DOI: doi:10.1073/pnas.2116506119
ISSN: 1091-6490
ASTM: PNASA6