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EMD-24273
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains)
EMD-24273
Single-particle3.0 Å
Deposition: 21/06/2021Map released: 23/03/2022
Last modified: 28/05/2025
Sample Organism:
Homo sapiens
Sample: human SARM1 in complex with NMN and 1AD
Fitted models: 7nal
Deposition Authors: Kerry PS, Nanson JD
Sample: human SARM1 in complex with NMN and 1AD
Fitted models: 7nal
Deposition Authors: Kerry PS, Nanson JD
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Shi Y ,
Kerry PS,
Nanson JD ,
Bosanac T,
Sasaki Y,
Krauss R,
Saikot FK ,
Adams SE,
Mosaiab T,
Masic V,
Mao X,
Rose F,
Vasquez E,
Furrer M,
Cunnea K,
Brearley A,
Gu W,
Luo Z,
Brillault L,
Landsberg MJ ,
DiAntonio A,
Kobe B ,
Milbrandt J,
Hughes RO,
Ve T
(2022) Mol Cell , 82 , 1643
,
Kerry PS,
Nanson JD ,
Bosanac T,
Sasaki Y,
Krauss R,
Saikot FK ,
Adams SE,
Mosaiab T,
Masic V,
Mao X,
Rose F,
Vasquez E,
Furrer M,
Cunnea K,
Brearley A,
Gu W,
Luo Z,
Brillault L,
Landsberg MJ ,
DiAntonio A,
Kobe B ,
Milbrandt J,
Hughes RO,
Ve T
(2022) Mol Cell , 82 , 1643
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): (Australia)
- Australian Research Council (ARC): (Australia)