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EMD-23898
SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-38 (three down conformation)
EMD-23898
Single-particle3.2 Å
Deposition: 24/04/2021Map released: 12/05/2021
Last modified: 21/05/2025
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Mus musculus
Sample: SARS-CoV-2 spike bound by SARS2-38 antibody Fab
Fitted models: 7mkl
Deposition Authors: Adams LJ
,
Fremont DH
Sample: SARS-CoV-2 spike bound by SARS2-38 antibody Fab
Fitted models: 7mkl
Deposition Authors: Adams LJ
,
Fremont DH
A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope.
VanBlargan LA ,
Adams LJ ,
Liu Z ,
Chen RE,
Gilchuk P,
Raju S,
Smith BK,
Zhao H ,
Case JB,
Winkler ES,
Whitener BM ,
Droit L,
Aziati ID,
Bricker TL,
Joshi A ,
Shi PY,
Creanga A,
Pegu A,
Handley SA,
Wang D,
Boon ACM ,
Crowe Jr JE,
Whelan SPJ,
Fremont DH ,
Diamond MS
(2021) Immunity , 54 , 2399 - 2416.e6
,
Adams LJ ,
Liu Z ,
Chen RE,
Gilchuk P,
Raju S,
Smith BK,
Zhao H ,
Case JB,
Winkler ES,
Whitener BM ,
Droit L,
Aziati ID,
Bricker TL,
Joshi A ,
Shi PY,
Creanga A,
Pegu A,
Handley SA,
Wang D,
Boon ACM ,
Crowe Jr JE,
Whelan SPJ,
Fremont DH ,
Diamond MS
(2021) Immunity , 54 , 2399 - 2416.e6