EMD-23766

Single-particle
4.5 Å
EMD-23766
3D View Gallery
Deposition: 03/04/2021
Map released: 23/02/2022
Last modified: 30/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-23766

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7md4 summary report (pdf.gz) Map-7md4 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists

EMD-23766

Single-particle
4.5 Å
EMD-23766
3D View Gallery
Deposition: 03/04/2021
Map released: 23/02/2022
Last modified: 30/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: IR-ECD dimer complexed with two IRPA-3 partial agonists
Fitted models: 7md4

Deposition Authors: Gomez-Llorente Y, Zhou H
Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Wu M, Carballo-Jane E, Zhou H , Zafian P, Dai G, Liu M, Lao J, Kelly T, Shao D, Gorski J, Pissarnitski D, Kekec A, Chen Y, Previs SF, Scapin G, Llorente YG, Hollingsworth SA , Yan L, Feng D, Huo P, Walford G, Erion MD, Kelley DE, Lin S, Mu J
(2022) Nat Commun , 13 , 942 - 942
PUBMED: 35177603
DOI: doi:10.1038/s41467-022-28561-9
ISSN: 2041-1723