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EMD-23766
Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists
EMD-23766
Single-particle4.5 Å
Deposition: 03/04/2021Map released: 23/02/2022
Last modified: 30/10/2024
Sample Organism:
Homo sapiens
Sample: IR-ECD dimer complexed with two IRPA-3 partial agonists
Fitted models: 7md4
Deposition Authors: Gomez-Llorente Y, Zhou H
Sample: IR-ECD dimer complexed with two IRPA-3 partial agonists
Fitted models: 7md4
Deposition Authors: Gomez-Llorente Y, Zhou H
Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Wu M,
Carballo-Jane E,
Zhou H ,
Zafian P,
Dai G,
Liu M,
Lao J,
Kelly T,
Shao D,
Gorski J,
Pissarnitski D,
Kekec A,
Chen Y,
Previs SF,
Scapin G,
Llorente YG,
Hollingsworth SA ,
Yan L,
Feng D,
Huo P,
Walford G,
Erion MD,
Kelley DE,
Lin S,
Mu J
(2022) Nat Commun , 13 , 942 - 942
,
Zafian P,
Dai G,
Liu M,
Lao J,
Kelly T,
Shao D,
Gorski J,
Pissarnitski D,
Kekec A,
Chen Y,
Previs SF,
Scapin G,
Llorente YG,
Hollingsworth SA ,
Yan L,
Feng D,
Huo P,
Walford G,
Erion MD,
Kelley DE,
Lin S,
Mu J
(2022) Nat Commun , 13 , 942 - 942