Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-23689

Helical reconstruction
4.1 Å
EMD-23689
3D View Gallery
Deposition: 25/03/2021
Map released: 22/09/2021
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-23689
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7m65 summary report (pdf.gz) Map and 7m65 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4

EMD-23689

Helical reconstruction
4.1 Å
EMD-23689
3D View Gallery
Deposition: 25/03/2021
Map released: 22/09/2021
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: hIAPP fibril
Fitted models: 7m65

Deposition Authors: Cao Q , Boyer DR
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Cao Q , Boyer DR, Sawaya MR , Abskharon R, Saelices L, Nguyen BA, Lu J, Murray KA, Kandeel F, Eisenberg DS
(2021) Nat Struct Mol Biol , 28 , 724 - 730
DOI: doi:10.1038/s41594-021-00646-x
ISSN: 1545-9985