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EMD-23662
Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of neutralizing antibodies REGN10985 and REGN10989
EMD-23662
Single-particle3.3 Å
Deposition: 19/03/2021Map released: 28/07/2021
Last modified: 20/11/2024
Sample Organism:
Homo sapiens,
Severe acute respiratory syndrome coronavirus 2
Sample: Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of neutralizing antibodies REGN10985 and REGN10989
Fitted models: 7m42
Deposition Authors: Zhou Y, Romero Hernandez A
Sample: Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of neutralizing antibodies REGN10985 and REGN10989
Fitted models: 7m42
Deposition Authors: Zhou Y, Romero Hernandez A
The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.
Copin R 
,
Baum A,
Wloga E,
Pascal KE,
Giordano S,
Fulton BO,
Zhou A,
Negron N,
Lanza K,
Chan N,
Coppola A,
Chiu J,
Ni M,
Wei Y,
Atwal GS,
Hernandez AR,
Saotome K,
Zhou Y,
Franklin MC,
Hooper AT ,
McCarthy S,
Hamon S,
Hamilton JD,
Staples HM,
Alfson K,
Carrion Jr R,
Ali S,
Norton T ,
Somersan-Karakaya S,
Sivapalasingam S,
Herman GA,
Weinreich DM,
Lipsich L,
Stahl N,
Murphy AJ,
Yancopoulos GD,
Kyratsous CA
(2021) Cell , 184 , 3949
,
Baum A,
Wloga E,
Pascal KE,
Giordano S,
Fulton BO,
Zhou A,
Negron N,
Lanza K,
Chan N,
Coppola A,
Chiu J,
Ni M,
Wei Y,
Atwal GS,
Hernandez AR,
Saotome K,
Zhou Y,
Franklin MC,
Hooper AT ,
McCarthy S,
Hamon S,
Hamilton JD,
Staples HM,
Alfson K,
Carrion Jr R,
Ali S,
Norton T ,
Somersan-Karakaya S,
Sivapalasingam S,
Herman GA,
Weinreich DM,
Lipsich L,
Stahl N,
Murphy AJ,
Yancopoulos GD,
Kyratsous CA
(2021) Cell , 184 , 3949