Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-23654

Single-particle
2.5 Å
EMD-23654
3D View Gallery
Deposition: 18/03/2021
Map released: 30/06/2021
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-23654
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7m3g summary report (pdf.gz) Map and 7m3g FULL report (pdf.gz)
EMICSS annotations (xml)

Asymmetric Activation of the Calcium Sensing Receptor Homodimer

EMD-23654

Single-particle
2.5 Å
EMD-23654
3D View Gallery
Deposition: 18/03/2021
Map released: 30/06/2021
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: active-state human extracellular calcium-sensing receptor complexed with positive allosteric modulators etelcalcetide and evocalcet
Fitted models: 7m3g

Deposition Authors: Gao Y , Robertson MJ , Zhang C, Meyerowitz JG , Panova O, Skiniotis G
Asymmetric activation of the calcium-sensing receptor homodimer.
Gao Y , Robertson MJ , Rahman SN , Seven AB, Zhang C, Meyerowitz JG , Panova O, Hannan FM , Thakker RV , Brauner-Osborne H , Mathiesen JM , Skiniotis G
(2021) Nature , 595 , 455 - 459
PUBMED: 34194040
DOI: doi:10.1038/s41586-021-03691-0
ISSN: 1476-4687
ASTM: NATUAS