Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-23609
PRMT5 bound to covalent PBM-site inhibitor BRD-6988
EMD-23609
Single-particle2.39 Å
Deposition: 10/03/2021Map released: 17/03/2021
Last modified: 06/11/2024
Sample Organism:
Homo sapiens
Sample: Hetero-octamer complex of PRMT5 and WDR77
Fitted models: 7m05
Deposition Authors: McMillan BJ, McKinney DC
Sample: Hetero-octamer complex of PRMT5 and WDR77
Fitted models: 7m05
Deposition Authors: McMillan BJ, McKinney DC
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
McKinney DC ,
McMillan BJ,
Ranaghan MJ ,
Moroco JA ,
Brousseau M ,
Mullin-Bernstein Z ,
O'Keefe M,
McCarren P,
Mesleh MF,
Mulvaney KM,
Robinson F,
Singh R,
Bajrami B,
Wagner FF,
Hilgraf R,
Drysdale MJ,
Campbell AJ,
Skepner A,
Timm DE,
Porter D,
Kaushik VK,
Sellers WR ,
Ianari A
(2021) J Med Chem , 64 , 11148 - 11168
,
McMillan BJ,
Ranaghan MJ ,
Moroco JA ,
Brousseau M ,
Mullin-Bernstein Z ,
O'Keefe M,
McCarren P,
Mesleh MF,
Mulvaney KM,
Robinson F,
Singh R,
Bajrami B,
Wagner FF,
Hilgraf R,
Drysdale MJ,
Campbell AJ,
Skepner A,
Timm DE,
Porter D,
Kaushik VK,
Sellers WR ,
Ianari A
(2021) J Med Chem , 64 , 11148 - 11168