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EMD-23576
Structure of human 20S proteasome with bound ML052.
EMD-23576
Single-particle3.4 Å
Deposition: 05/03/2021Map released: 22/09/2021
Last modified: 14/05/2025
Sample Organism:
Homo sapiens,
Plasmodium falciparum 3D7
Sample: Homo sapiens 20S proteasome complexed with ML052
Fitted models: 7lxv
Deposition Authors: Hanssen E
,
Xie SC ,
Liu B ,
Leis AP,
Morton CJ ,
Metcalfe RD ,
Tilley L ,
Griffin MDW
Sample: Homo sapiens 20S proteasome complexed with ML052
Fitted models: 7lxv
Deposition Authors: Hanssen E
,
Xie SC ,
Liu B ,
Leis AP,
Morton CJ ,
Metcalfe RD ,
Tilley L ,
Griffin MDW
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Xie SC ,
Metcalfe RD ,
Mizutani H ,
Puhalovich T,
Hanssen E ,
Morton CJ ,
Du Y ,
Dogovski C,
Huang SC ,
Ciavarri J ,
Hales P ,
Griffin RJ ,
Cohen LH ,
Chuang BC,
Wittlin S,
Deni I ,
Yeo T ,
Ward KE ,
Barry DC ,
Liu B ,
Gillett DL ,
Crespo-Fernandez BF ,
Ottilie S ,
Mittal N,
Churchyard A,
Ferguson D ,
Aguiar ACC ,
Guido RVC ,
Baum J ,
Hanson KK ,
Winzeler EA ,
Gamo FJ ,
Fidock DA ,
Baud D,
Parker MW ,
Brand S ,
Dick LR ,
Griffin MDW ,
Gould AE ,
Tilley L
(2021) PNAS , 118
,
Metcalfe RD ,
Mizutani H ,
Puhalovich T,
Hanssen E ,
Morton CJ ,
Du Y ,
Dogovski C,
Huang SC ,
Ciavarri J ,
Hales P ,
Griffin RJ ,
Cohen LH ,
Chuang BC,
Wittlin S,
Deni I ,
Yeo T ,
Ward KE ,
Barry DC ,
Liu B ,
Gillett DL ,
Crespo-Fernandez BF ,
Ottilie S ,
Mittal N,
Churchyard A,
Ferguson D ,
Aguiar ACC ,
Guido RVC ,
Baum J ,
Hanson KK ,
Winzeler EA ,
Gamo FJ ,
Fidock DA ,
Baud D,
Parker MW ,
Brand S ,
Dick LR ,
Griffin MDW ,
Gould AE ,
Tilley L
(2021) PNAS , 118
Grant Support:
- Global Health Innovative Technology Fund: RFP-HTLP-H2019-101 (United States)
- Australian Research Council (ARC): FL150100106 (Australia)