EMD-23574

Single-particle
3.4 Å
EMD-23574
3D View Gallery
Deposition: 05/03/2021
Map released: 22/09/2021
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-23574

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7lxt summary report (pdf.gz) Map-7lxt FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of Plasmodium falciparum 20S proteasome with bound bortezomib.

EMD-23574

Single-particle
3.4 Å
EMD-23574
3D View Gallery
Deposition: 05/03/2021
Map released: 22/09/2021
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Plasmodium falciparum (isolate 3D7)
Sample: Plasmodium falciparum 20S proteasome complexed with bortezomib
Fitted models: 7lxt

Deposition Authors: Liu B , Hanssen E , Leis AP, Xie SC , Morton CJ , Metcalfe RD , Tilley L , Griffin MDW
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Xie SC , Metcalfe RD , Mizutani H , Puhalovich T, Hanssen E , Morton CJ , Du Y , Dogovski C, Huang SC , Ciavarri J , Hales P , Griffin RJ , Cohen LH , Chuang BC, Wittlin S, Deni I , Yeo T , Ward KE , Barry DC , Liu B , Gillett DL , Crespo-Fernandez BF , Ottilie S , Mittal N, Churchyard A, Ferguson D , Aguiar ACC , Guido RVC , Baum J , Hanson KK , Winzeler EA , Gamo FJ , Fidock DA , Baud D, Parker MW , Brand S , Dick LR , Griffin MDW , Gould AE , Tilley L
(2021) PNAS , 118
PUBMED: 34548400
DOI: doi:10.1073/pnas.2107213118
ISSN: 1091-6490
ASTM: PNASA6