EMD-23425
Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
EMD-23425
Single-particle3.7 Å
Deposition: 04/02/2021Map released: 12/01/2022
Last modified: 04/06/2025
Sample Organism:
Homo sapiens,
Lama glama,
Heloderma suspectum
Sample: Exendin-4-GLP-1R-Gs complex
Fitted models: 7lll
Deposition Authors: Wootten D
,
Sexton PM
Sample: Exendin-4-GLP-1R-Gs complex
Fitted models: 7lll
Deposition Authors: Wootten D
,
Sexton PM
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
Deganutti G ,
Liang YL,
Zhang X,
Khoshouei M,
Clydesdale L,
Belousoff MJ ,
Venugopal H ,
Truong TT,
Glukhova A ,
Keller AN,
Gregory KJ ,
Leach K ,
Christopoulos A ,
Danev R ,
Reynolds CA ,
Zhao P ,
Sexton PM ,
Wootten D
(2022) Nat Commun , 13 , 92 - 92
,
Liang YL,
Zhang X,
Khoshouei M,
Clydesdale L,
Belousoff MJ ,
Venugopal H ,
Truong TT,
Glukhova A ,
Keller AN,
Gregory KJ ,
Leach K ,
Christopoulos A ,
Danev R ,
Reynolds CA ,
Zhao P ,
Sexton PM ,
Wootten D
(2022) Nat Commun , 13 , 92 - 92
Grant Support:
- Australian Research Council (ARC): IC200100052 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1126857 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1184726 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1150083 (Australia)
- Japan Science and Technology: 18069571 (Japan)