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EMD-23408
Chicken Scap D435V L1-L7 domain / Fab complex focused map
EMD-23408
Single-particle3.5 Å
Deposition: 02/02/2021Map released: 30/06/2021
Last modified: 28/05/2025
Sample Organism:
Mus musculus,
Gallus gallus
Sample: Ternary complex of Scap with Fab fragment
Fitted models: 7lkh
Deposition Authors: Kober DL
,
Radhakrishnan A
Sample: Ternary complex of Scap with Fab fragment
Fitted models: 7lkh
Deposition Authors: Kober DL
,
Radhakrishnan A
Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.
Kober DL
,
Radhakrishnan A
,
Goldstein JL,
Brown MS,
Clark LD,
Bai XC,
Rosenbaum DM
(2021) Cell , 184 , 3689
,
Radhakrishnan A
,
Goldstein JL,
Brown MS,
Clark LD,
Bai XC,
Rosenbaum DM
(2021) Cell , 184 , 3689
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM116387 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): P01HL020948 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01GM136976 (United States)
- Welch Foundation: I-1770 (United States)
- Welch Foundation: I-1793 (United States)
- Welch Foundation: I-1944 (United States)
- Mallinckrodt Foundation: (United States)
- Leducq Foundation: 19CVD04 (France)
- Cancer Prevention and Research Institute of Texas (CPRIT): RR160082 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP170644 (United States)
- American Heart Association: 18POST34080141 (United States)
