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EMD-23280
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand
EMD-23280
Single-particle3.2 Å
Deposition: 12/01/2021Map released: 08/09/2021
Last modified: 13/11/2024
Sample Organism:
Homo sapiens
Sample: Human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist adenosine
Fitted models: 7ld3
Deposition Authors: Draper-Joyce CJ
,
Danev R
Sample: Human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist adenosine
Fitted models: 7ld3
Deposition Authors: Draper-Joyce CJ
,
Danev R
Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.
Draper-Joyce CJ ,
Bhola R,
Wang J ,
Bhattarai A,
Nguyen ATN ,
Cowie-Kent I,
O'Sullivan K ,
Chia LY,
Venugopal H ,
Valant C ,
Thal DM ,
Wootten D ,
Panel N ,
Carlsson J ,
Christie MJ ,
White PJ,
Scammells P,
May LT ,
Sexton PM ,
Danev R ,
Miao Y ,
Glukhova A ,
Imlach WL ,
Christopoulos A
(2021) Nature , 597 , 571 - 576
,
Bhola R,
Wang J ,
Bhattarai A,
Nguyen ATN ,
Cowie-Kent I,
O'Sullivan K ,
Chia LY,
Venugopal H ,
Valant C ,
Thal DM ,
Wootten D ,
Panel N ,
Carlsson J ,
Christie MJ ,
White PJ,
Scammells P,
May LT ,
Sexton PM ,
Danev R ,
Miao Y ,
Glukhova A ,
Imlach WL ,
Christopoulos A
(2021) Nature , 597 , 571 - 576
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): (Australia)
- Australian Research Council (ARC): (Australia)