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EMD-23278
Cryo-EM structure of ligand-free Human SARM1
EMD-23278
Single-particle3.1 Å
Deposition: 12/01/2021Map released: 10/03/2021
Last modified: 14/05/2025
Sample Organism:
Homo sapiens
Sample: homo-octameric SARM1
Fitted models: 7ld0
Deposition Authors: Nanson JD
,
Gu W
Sample: homo-octameric SARM1
Fitted models: 7ld0
Deposition Authors: Nanson JD
,
Gu W
SARM1 is a metabolic sensor activated by an increased NMN/NAD + ratio to trigger axon degeneration.
Figley MD ,
Gu W ,
Nanson JD ,
Shi Y ,
Sasaki Y,
Cunnea K,
Malde AK ,
Jia X,
Luo Z,
Saikot FK ,
Mosaiab T,
Masic V,
Holt S,
Hartley-Tassell L,
McGuinness HY ,
Manik MK,
Bosanac T,
Landsberg MJ ,
Kerry PS,
Mobli M,
Hughes RO,
Milbrandt J,
Kobe B ,
DiAntonio A,
Ve T
(2021) Neuron , 109 , 1118
,
Gu W ,
Nanson JD ,
Shi Y ,
Sasaki Y,
Cunnea K,
Malde AK ,
Jia X,
Luo Z,
Saikot FK ,
Mosaiab T,
Masic V,
Holt S,
Hartley-Tassell L,
McGuinness HY ,
Manik MK,
Bosanac T,
Landsberg MJ ,
Kerry PS,
Mobli M,
Hughes RO,
Milbrandt J,
Kobe B ,
DiAntonio A,
Ve T
(2021) Neuron , 109 , 1118
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): 1107804 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1160570 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1071659 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1108859 (Australia)
- Australian Research Council (ARC): FL180100109 (Australia)
- Australian Research Council (ARC): DE170100783 (Australia)