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EMD-23098
Cryo-EM structure of the VRC316 clinical trial, vaccine-elicited, human antibody 316-310-1B11 in complex with an H2 CAN05 HA trimer
EMD-23098
Single-particle2.85 Å
Deposition: 11/12/2020Map released: 03/11/2021
Last modified: 13/11/2024
Sample Organism:
Homo sapiens,
Influenza A virus (A/Canada/720/2005(H2N2)),
Influenza A virus
Sample: 316-310-1B11 Fab in complex with an H2 CAN05 HA trimer
Fitted models: 7l0l
Deposition Authors: Gorman J
,
Kwong PD
Sample: 316-310-1B11 Fab in complex with an H2 CAN05 HA trimer
Fitted models: 7l0l
Deposition Authors: Gorman J
,
Kwong PD
A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination.
Andrews SF ,
Raab JE,
Gorman J ,
Gillespie RA ,
Cheung CSF,
Rawi R,
Cominsky LY ,
Boyington JC,
Creanga A ,
Shen CH,
Harris DR ,
Olia AS,
Nazzari AF,
Zhou T ,
Houser KV ,
Chen GL,
Mascola JR,
Graham BS,
Kanekiyo M ,
Ledgerwood JE,
Kwong PD ,
McDermott AB
(2022) Nat Med , 28 , 373 - 382
,
Raab JE,
Gorman J ,
Gillespie RA ,
Cheung CSF,
Rawi R,
Cominsky LY ,
Boyington JC,
Creanga A ,
Shen CH,
Harris DR ,
Olia AS,
Nazzari AF,
Zhou T ,
Houser KV ,
Chen GL,
Mascola JR,
Graham BS,
Kanekiyo M ,
Ledgerwood JE,
Kwong PD ,
McDermott AB
(2022) Nat Med , 28 , 373 - 382
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM103310 (United States)
- Other private: Simons Foundation (SF349247) (United States)