EMD-22922
ACE2-RBD Focused Refinement Using Symmetry Expansion of Applied C3 for Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 7.4
EMD-22922
Single-particle3.39 Å
Deposition: 02/11/2020Map released: 09/12/2020
Last modified: 16/10/2024
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Homo sapiens
Sample: ACE2-RBD pH 7.4
Fitted models: 7kmb
Deposition Authors: Gorman J
,
Kwong PD
Sample: ACE2-RBD pH 7.4
Fitted models: 7kmb
Deposition Authors: Gorman J
,
Kwong PD
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Zhou T ,
Tsybovsky Y,
Gorman J ,
Rapp M,
Cerutti G ,
Chuang GY,
Katsamba PS ,
Sampson JM ,
Schon A,
Bimela J,
Boyington JC,
Nazzari A ,
Olia AS,
Shi W,
Sastry M,
Stephens T,
Stuckey J,
Teng IT,
Wang P,
Wang S,
Zhang B,
Friesner RA,
Ho DD,
Mascola JR,
Shapiro L,
Kwong PD
(2020) Cell Host Microbe , 28 , 867 - 879.e5
,
Tsybovsky Y,
Gorman J ,
Rapp M,
Cerutti G ,
Chuang GY,
Katsamba PS ,
Sampson JM ,
Schon A,
Bimela J,
Boyington JC,
Nazzari A ,
Olia AS,
Shi W,
Sastry M,
Stephens T,
Stuckey J,
Teng IT,
Wang P,
Wang S,
Zhang B,
Friesner RA,
Ho DD,
Mascola JR,
Shapiro L,
Kwong PD
(2020) Cell Host Microbe , 28 , 867 - 879.e5
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): U24 GM129539 (United States)
- Other private: SF349247 (Simons Foundation) (United States)