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EMD-22907
SARS-CoV-2 Spike bound to Nb6 in closed conformation
EMD-22907
Single-particle3.03 Å
Deposition: 27/10/2020Map released: 11/11/2020
Last modified: 16/10/2024
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
synthetic construct
Sample: Complex of Spike S2P glycoprotein with synthetic nanobody Nb6
Fitted models: 7kkk
Deposition Authors: Schoof MS, Faust BF
Sample: Complex of Spike S2P glycoprotein with synthetic nanobody Nb6
Fitted models: 7kkk
Deposition Authors: Schoof MS, Faust BF
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Schoof M 
,
Faust B ,
Saunders RA ,
Sangwan S ,
Rezelj V,
Hoppe N ,
Boone M ,
Billesbolle CB ,
Puchades C ,
Azumaya CM ,
Kratochvil HT ,
Zimanyi M ,
Deshpande I ,
Liang J ,
Dickinson S,
Nguyen HC ,
Chio CM ,
Merz GE ,
Thompson MC ,
Diwanji D ,
Schaefer K ,
Anand AA ,
Dobzinski N ,
Zha BS ,
Simoneau CR,
Leon K ,
White KM,
Chio US ,
Gupta M ,
Jin M ,
Li F ,
Liu Y,
Zhang K ,
Bulkley D ,
Sun M ,
Smith AM ,
Rizo AN ,
Moss F,
Brilot AF ,
Pourmal S ,
Trenker R ,
Pospiech T,
Gupta S,
Barsi-Rhyne B,
Belyy V ,
Barile-Hill AW,
Nock S,
Liu Y,
Krogan NJ ,
Ralston CY,
Swaney DL ,
Garcia-Sastre A ,
Ott M,
Vignuzzi M,
QCRG Structural Biology Consortium,
Walter P ,
Manglik A
(2020) Science , 370 , 1473 - 1479
,
Faust B ,
Saunders RA ,
Sangwan S ,
Rezelj V,
Hoppe N ,
Boone M ,
Billesbolle CB ,
Puchades C ,
Azumaya CM ,
Kratochvil HT ,
Zimanyi M ,
Deshpande I ,
Liang J ,
Dickinson S,
Nguyen HC ,
Chio CM ,
Merz GE ,
Thompson MC ,
Diwanji D ,
Schaefer K ,
Anand AA ,
Dobzinski N ,
Zha BS ,
Simoneau CR,
Leon K ,
White KM,
Chio US ,
Gupta M ,
Jin M ,
Li F ,
Liu Y,
Zhang K ,
Bulkley D ,
Sun M ,
Smith AM ,
Rizo AN ,
Moss F,
Brilot AF ,
Pourmal S ,
Trenker R ,
Pospiech T,
Gupta S,
Barsi-Rhyne B,
Belyy V ,
Barile-Hill AW,
Nock S,
Liu Y,
Krogan NJ ,
Ralston CY,
Swaney DL ,
Garcia-Sastre A ,
Ott M,
Vignuzzi M,
QCRG Structural Biology Consortium,
Walter P ,
Manglik A
(2020) Science , 370 , 1473 - 1479
Grant Support:
- Other private: (United States)