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EMD-22689

Single-particle
3.4 Å
EMD-22689
3D View Gallery
Deposition: 18/09/2020
Map released: 17/03/2021
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-22689
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7k65 summary report (pdf.gz) Map and 7k65 FULL report (pdf.gz)
EMICSS annotations (xml)

Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23

EMD-22689

Single-particle
3.4 Å
EMD-22689
3D View Gallery
Deposition: 18/09/2020
Map released: 17/03/2021
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Lama glama
Sample: Complex between Hedgehog receptor PTCH1 and nanobody TI23
Fitted models: 7k65

Deposition Authors: Zhang Y , Bulkley DP
Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.
Zhang Y , Lu WJ , Bulkley DP, Liang J, Ralko A, Han S , Roberts KJ, Li A, Cho W, Cheng Y , Manglik A , Beachy PA
(2020) PNAS , 117 , 28838 - 28846
PUBMED: 33139559
DOI: doi:10.1073/pnas.2011560117
ISSN: 1091-6490
ASTM: PNASA6