EMD-22490
Structure of human TRPA1 in complex with antagonist compound 21
EMD-22490
Single-particle3.05 Å
Deposition: 20/08/2020Map released: 31/03/2021
Last modified: 06/03/2024
Sample Organism:
Homo sapiens
Sample: TRPA1 bound by antagonist compound 21
Fitted models: 7jup
Deposition Authors: Rohou A, Rouge L, Chen H
Sample: TRPA1 bound by antagonist compound 21
Fitted models: 7jup
Deposition Authors: Rohou A, Rouge L, Chen H
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
Terrett JA ,
Chen H ,
Shore DG,
Villemure E,
Larouche-Gauthier R,
Dery M,
Beaumier F,
Constantineau-Forget L,
Grand-Maitre C,
Lepissier L,
Ciblat S,
Sturino C,
Chen Y,
Hu B,
Lu A,
Wang Y,
Cridland AP,
Ward SI,
Hackos DH,
Reese RM,
Shields SD ,
Chen J,
Balestrini A,
Riol-Blanco L,
Lee WP,
Liu J,
Suto E,
Wu X,
Zhang J,
Ly JQ,
La H,
Johnson K ,
Baumgardner M,
Chou KJ,
Rohou A,
Rouge L,
Safina BS ,
Magnuson S,
Volgraf M
(2021) J Med Chem , 64 , 3843 - 3869
,
Chen H ,
Shore DG,
Villemure E,
Larouche-Gauthier R,
Dery M,
Beaumier F,
Constantineau-Forget L,
Grand-Maitre C,
Lepissier L,
Ciblat S,
Sturino C,
Chen Y,
Hu B,
Lu A,
Wang Y,
Cridland AP,
Ward SI,
Hackos DH,
Reese RM,
Shields SD ,
Chen J,
Balestrini A,
Riol-Blanco L,
Lee WP,
Liu J,
Suto E,
Wu X,
Zhang J,
Ly JQ,
La H,
Johnson K ,
Baumgardner M,
Chou KJ,
Rohou A,
Rouge L,
Safina BS ,
Magnuson S,
Volgraf M
(2021) J Med Chem , 64 , 3843 - 3869