EMD-22265
Cryo-EM structure of BCL6 bound to BI-3802
EMD-22265
Single-particle3.7 Å
Deposition: 01/07/2020Map released: 25/11/2020
Last modified: 06/03/2024
Sample Organism:
Homo sapiens
Sample: B-cell lymphoma 6 protein (BCL6) filament
Fitted models: 6xmx
Deposition Authors: Yoon H
,
Burman SSR
Sample: B-cell lymphoma 6 protein (BCL6) filament
Fitted models: 6xmx
Deposition Authors: Yoon H
,
Burman SSR
Small-molecule-induced polymerization triggers degradation of BCL6.
Slabicki M ,
Yoon H ,
Koeppel J ,
Nitsch L ,
Roy Burman SS ,
Di Genua C,
Donovan KA ,
Sperling AS ,
Hunkeler M ,
Tsai JM,
Sharma R,
Guirguis A ,
Zou C,
Chudasama P,
Gasser JA,
Miller PG,
Scholl C ,
Frohling S ,
Nowak RP ,
Fischer ES ,
Ebert BL
(2020) Nature , 588 , 164 - 168
,
Yoon H ,
Koeppel J ,
Nitsch L ,
Roy Burman SS ,
Di Genua C,
Donovan KA ,
Sperling AS ,
Hunkeler M ,
Tsai JM,
Sharma R,
Guirguis A ,
Zou C,
Chudasama P,
Gasser JA,
Miller PG,
Scholl C ,
Frohling S ,
Nowak RP ,
Fischer ES ,
Ebert BL
(2020) Nature , 588 , 164 - 168
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01CA218278 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01CA218278 (United States)
- Swiss National Science Foundation: 174331 (Switzerland)
- The Mark Foundation: (United States)