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EMD-21927
Structure of human Frizzled5 by fiducial-assisted cryo-EM
EMD-21927
Single-particle3.7 Å
Deposition: 07/05/2020Map released: 19/08/2020
Last modified: 06/11/2024
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Fzd5-BRIL/Fab/Nb complex
Fitted models: 6ww2
Deposition Authors: Tsutsumi N
,
Jude KM ,
Gati C ,
Garcia KC
Sample: Fzd5-BRIL/Fab/Nb complex
Fitted models: 6ww2
Deposition Authors: Tsutsumi N
,
Jude KM ,
Gati C ,
Garcia KC
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Tsutsumi N ,
Mukherjee S ,
Waghray D,
Janda CY ,
Jude KM ,
Miao Y ,
Burg JS,
Aduri NG,
Kossiakoff AA,
Gati C ,
Garcia KC
(2020) eLife , 9
,
Mukherjee S ,
Waghray D,
Janda CY ,
Jude KM ,
Miao Y ,
Burg JS,
Aduri NG,
Kossiakoff AA,
Gati C ,
Garcia KC
(2020) eLife , 9
Grant Support:
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): 1R01DK115728 (United States)
- Department of Energy (DOE, United States): DE-AC02-76SF00515 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)