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EMD-20883
CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide
EMD-20883
Single-particle3.0 Å
Deposition: 30/10/2019Map released: 25/03/2020
Last modified: 04/06/2025
Sample Organism:
Homo sapiens,
Lama glama
Sample: AM:CLR:RAMP2:GasDN:Gb1:Gg2:Nb35 GPCR Complex
Fitted models: 6uun
Deposition Authors: Belousoff MJ
,
Liang YL
Sample: AM:CLR:RAMP2:GasDN:Gb1:Gg2:Nb35 GPCR Complex
Fitted models: 6uun
Deposition Authors: Belousoff MJ
,
Liang YL
Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Liang YL,
Belousoff MJ ,
Fletcher MM ,
Zhang X ,
Khoshouei M,
Deganutti G ,
Koole C,
Furness SGB ,
Miller LJ,
Hay DL ,
Christopoulos A,
Reynolds CA ,
Danev R,
Wootten D ,
Sexton PM
(2020) Acs Pharmacol Transl Sci , 3 , 263 - 284
,
Fletcher MM ,
Zhang X ,
Khoshouei M,
Deganutti G ,
Koole C,
Furness SGB ,
Miller LJ,
Hay DL ,
Christopoulos A,
Reynolds CA ,
Danev R,
Wootten D ,
Sexton PM
(2020) Acs Pharmacol Transl Sci , 3 , 263 - 284
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): 1120919 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1159006 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1150083 (Australia)
- Japan Society for the Promotion of Science (JSPS): KAKENHI #18H06043 (Japan)
- Japan Science and Technology: #18069571 (Japan)