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EMD-20759

Helical reconstruction
2.5 Å
EMD-20759
3D View Gallery
Deposition: 24/09/2019
Map released: 19/02/2020
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-20759
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 6ufr summary report (pdf.gz) Map and 6ufr FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of recombinantly assembled E46K alpha-synuclein fibrils

EMD-20759

Helical reconstruction
2.5 Å
EMD-20759
3D View Gallery
Deposition: 24/09/2019
Map released: 19/02/2020
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Recombinantly assembled E46K alpha-synuclein fibril
Fitted models: 6ufr

Deposition Authors: Eisenberg DS, Boyer DR
The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
Boyer DR , Li B, Sun C, Fan W, Zhou K , Hughes MP , Sawaya MR , Jiang L, Eisenberg DS
(2020) PNAS , 117 , 3592 - 3602
PUBMED: 32015135
DOI: doi:10.1073/pnas.1917914117
ISSN: 1091-6490
ASTM: PNASA6