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EMD-19986
Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo
EMD-19986
Helical reconstruction1.93 Å
Deposition: 28/03/2024Map released: 05/06/2024
Last modified: 24/12/2025
Sample Organism:
Homo sapiens
Sample: recombinant alpha-synuclein fibril
Fitted models: 9euu
Deposition Authors: Burger D
,
Kashyrina M,
Lewis A,
De Nuccio F,
Mohammed I,
de La Seigliere H ,
van den Heuvel L ,
Feuillie C,
Verchere J,
Berbon M,
Arotcarena M,
Retailleau A ,
Bezard E ,
Laferriere F ,
Loquet A ,
Bousset L ,
Baron T ,
Lofrumento DD,
De Giorgi F,
Stahlberg H ,
Ichas F
Sample: recombinant alpha-synuclein fibril
Fitted models: 9euu
Deposition Authors: Burger D
,
Kashyrina M,
Lewis A,
De Nuccio F,
Mohammed I,
de La Seigliere H ,
van den Heuvel L ,
Feuillie C,
Verchere J,
Berbon M,
Arotcarena M,
Retailleau A ,
Bezard E ,
Laferriere F ,
Loquet A ,
Bousset L ,
Baron T ,
Lofrumento DD,
De Giorgi F,
Stahlberg H ,
Ichas F
Synthetic alpha-synuclein fibrils replicate in mice causing MSA-like pathology.
Burger D ,
Kashyrina M,
van den Heuvel L ,
de La Seigliere H ,
Lewis AJ,
De Nuccio F,
Mohammed I,
Verchere J,
Feuillie C,
Berbon M,
Arotcarena ML,
Retailleau A ,
Bezard E ,
Canron MH,
Meissner WG ,
Loquet A ,
Bousset L ,
Poujol C ,
Nilsson KPR,
Laferriere F ,
Baron T ,
Lofrumento DD,
De Giorgi F,
Stahlberg H ,
Ichas F
(2025) Nature , 648 , 409 - 417
,
Kashyrina M,
van den Heuvel L ,
de La Seigliere H ,
Lewis AJ,
De Nuccio F,
Mohammed I,
Verchere J,
Feuillie C,
Berbon M,
Arotcarena ML,
Retailleau A ,
Bezard E ,
Canron MH,
Meissner WG ,
Loquet A ,
Bousset L ,
Poujol C ,
Nilsson KPR,
Laferriere F ,
Baron T ,
Lofrumento DD,
De Giorgi F,
Stahlberg H ,
Ichas F
(2025) Nature , 648 , 409 - 417
Grant Support:
- Swiss National Science Foundation: 514605 (Switzerland)