EMD-19979

Single-particle
3.0 Å
EMD-19979
3D View Gallery
Deposition: 27/03/2024
Map released: 24/07/2024
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19979
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9eup summary report (pdf.gz) Map and 9eup FULL report (pdf.gz)
EMICSS annotations (xml)

Inhibitor-free outward-open structure of Drosophila dopamine transporter

EMD-19979

Single-particle
3.0 Å
EMD-19979
3D View Gallery
Deposition: 27/03/2024
Map released: 24/07/2024
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Drosophila melanogaster, Mus musculus
Sample: Inhibitor-free Drosophila melanogaster dopamine transporter in complex with Fab 9D5
Fitted models: 9eup

Deposition Authors: Pedersen CN , Yang F, Ita S, Xu Y, Akunuri R, Trampari S, Neumann CMT, Desdorf LM , Schioett B, Salvino JM, Mortensen OV , Nissen P , Shahsavar A
Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
Pedersen CN , Yang F, Ita S, Xu Y, Akunuri R, Trampari S, Neumann CMT, Desdorf LM , Schiott B , Salvino JM, Mortensen OV , Nissen P , Shahsavar A
(2024) J.Neurochem. , 168 , 2043 - 2055
PUBMED: 39010681
DOI: doi:10.1111/jnc.16179
ISSN: 1471-4159