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EMD-19979
Inhibitor-free outward-open structure of Drosophila dopamine transporter
EMD-19979
Single-particle3.0 Å
Deposition: 27/03/2024Map released: 24/07/2024
Last modified: 20/11/2024
Sample Organism:
Drosophila melanogaster,
Mus musculus
Sample: Inhibitor-free Drosophila melanogaster dopamine transporter in complex with Fab 9D5
Fitted models: 9eup
Deposition Authors: Pedersen CN
,
Yang F,
Ita S,
Xu Y,
Akunuri R,
Trampari S,
Neumann CMT,
Desdorf LM ,
Schioett B,
Salvino JM,
Mortensen OV ,
Nissen P ,
Shahsavar A
Sample: Inhibitor-free Drosophila melanogaster dopamine transporter in complex with Fab 9D5
Fitted models: 9eup
Deposition Authors: Pedersen CN
,
Yang F,
Ita S,
Xu Y,
Akunuri R,
Trampari S,
Neumann CMT,
Desdorf LM ,
Schioett B,
Salvino JM,
Mortensen OV ,
Nissen P ,
Shahsavar A
Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
Pedersen CN ,
Yang F,
Ita S,
Xu Y,
Akunuri R,
Trampari S,
Neumann CMT,
Desdorf LM ,
Schiott B ,
Salvino JM,
Mortensen OV ,
Nissen P ,
Shahsavar A
(2024) J.Neurochem. , 168 , 2043 - 2055
,
Yang F,
Ita S,
Xu Y,
Akunuri R,
Trampari S,
Neumann CMT,
Desdorf LM ,
Schiott B ,
Salvino JM,
Mortensen OV ,
Nissen P ,
Shahsavar A
(2024) J.Neurochem. , 168 , 2043 - 2055
Grant Support:
- Novo Nordisk Foundation: NNF19OC0054875 (Denmark)
- Lundbeckfonden: R310-2018-3713 (Denmark)
- Danish Ministry for Research and Higher Education: 5072-00025B (Denmark)
- National Institutes of Health/National Institute of Mental Health (NIH/NIMH): MH121453 (United States)
- National Institutes of Health/National Institute of Mental Health (NIH/NIMH): MH106912 (United States)
- Lundbeckfonden: R368-2021-522 (Denmark)
- Novo Nordisk Foundation: NNF18OC0032608 (Denmark)
- Aarhus University Research Foundation: AUFF-E-2022-9-24 (Denmark)
- National Institutes of Health/National Library of Medicine (NIH/NLM): R01 DA051205-03 (United States)
- National Institutes of Health/National Library of Medicine (NIH/NLM): S10OD030245-01 (United States)
- National Institutes of Health/National Library of Medicine (NIH/NLM): P30 CA010815-53 (United States)