EMD-19978

Single-particle
3.2 Å
EMD-19978
3D View Gallery
Deposition: 27/03/2024
Map released: 24/07/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19978

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9euo summary report (pdf.gz) Map-9euo FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Outward-open structure of Drosophila dopamine transporter bound to an atypical non-competitive inhibitor

EMD-19978

Single-particle
3.2 Å
EMD-19978
3D View Gallery
Deposition: 27/03/2024
Map released: 24/07/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Drosophila melanogaster, Mus musculus
Sample: Drosophila melanogaster dopamine transporter bound to atypical inhibitor AC-4-248 and in complex with Fab 9D5
Fitted models: 9euo

Deposition Authors: Pedersen CN , Yang F, Ita S, Xu Y, Akunuri R, Trampari S, Neumann CMT, Desdorf LM , Schioett B, Salvino JM , Mortensen OV , Nissen P , Shahsavar A
Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
Pedersen CN , Yang F, Ita S, Xu Y, Akunuri R, Trampari S, Neumann CMT, Desdorf LM , Schiott B , Salvino JM , Mortensen OV , Nissen P , Shahsavar A
(2024) J.Neurochem. , 168 , 2043 - 2055
PUBMED: 39010681
DOI: doi:10.1111/jnc.16179
ISSN: 1471-4159