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EMD-19869
Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02)
EMD-19869
Single-particle3.02 Å
Deposition: 15/03/2024Map released: 13/11/2024
Last modified: 26/03/2025
Sample Organism:
Homo sapiens,
Vicugna pacos
Sample: CerS6-Nb02 complex
Fitted models: 9eot
Deposition Authors: Pascoa TC
,
Pike ACW ,
Chi G ,
Stefanic S ,
Quigley A ,
Chalk R,
Mukhopadhyay SMM,
Venkaya S,
Dix C,
Moreira T,
Tessitore A,
Cole V,
Chu A,
Elkins JM,
Pautsch A,
Schnapp G ,
Carpenter EP ,
Sauer DB
Sample: CerS6-Nb02 complex
Fitted models: 9eot
Deposition Authors: Pascoa TC
,
Pike ACW ,
Chi G ,
Stefanic S ,
Quigley A ,
Chalk R,
Mukhopadhyay SMM,
Venkaya S,
Dix C,
Moreira T,
Tessitore A,
Cole V,
Chu A,
Elkins JM,
Pautsch A,
Schnapp G ,
Carpenter EP ,
Sauer DB
Structural basis of the mechanism and inhibition of a human ceramide synthase.
Pascoa TC ,
Pike ACW ,
Tautermann CS ,
Chi G ,
Traub M,
Quigley A ,
Chalk R,
Stefanic S ,
Thamm S,
Pautsch A,
Carpenter EP ,
Schnapp G ,
Sauer DB
(2025) Nat Struct Mol Biol , 32 , 431 - 440
,
Pike ACW ,
Tautermann CS ,
Chi G ,
Traub M,
Quigley A ,
Chalk R,
Stefanic S ,
Thamm S,
Pautsch A,
Carpenter EP ,
Schnapp G ,
Sauer DB
(2025) Nat Struct Mol Biol , 32 , 431 - 440
Grant Support:
- Wellcome Trust: 102164/B/15/Z (United Kingdom)
- Wellcome Trust: 106169/Z/14/Z (United Kingdom)