EMD-19777

Single-particle
3.2 Å
EMD-19777
3D View Gallery
Deposition: 01/03/2024
Map released: 08/10/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19777

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8s7k summary report (pdf.gz) Map-8s7k FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

M. tuberculosis gyrase holocomplex with 150 bp DNA and gepotidacin

EMD-19777

Single-particle
3.2 Å
EMD-19777
3D View Gallery
Deposition: 01/03/2024
Map released: 08/10/2025
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mycobacterium tuberculosis, synthetic construct
Sample: Cryo-EM structure of Mtb DNA Gyrase in complex with DNA and Gepotidacin
Fitted models: 8s7k

Deposition Authors: Mechaly A , Gubellini F, Yab E, Willand N, Petrella S , Dreneau A, Gioia B, Piveteau C, Djaout K, Lecat E, Wehenkel AM, Gubellini F, Mechaly A , Alzari PM, Deprez B, Baulard A , Aubry A, Willand N, Petrella S
Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase.
Gedeon A , Yab E, Dinut A, Sadowski E, Capton E, Dreneau A, Petit J, Gioia B, Piveteau C, Djaout K, Lecat E, Wehenkel AM, Gubellini F, Mechaly A , Alzari PM, Deprez B, Baulard A , Aubry A, Willand N, Petrella S
(2024) iScience , 27 , 110967 - 110967
PUBMED: 39429773
DOI: doi:10.1016/j.isci.2024.110967
ISSN: 2589-0042