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EMD-19628

Single-particle
2.3 Å
EMD-19628
3D View Gallery
Deposition: 14/02/2024
Map released: 25/12/2024
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19628
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8s0t summary report (pdf.gz) Map and 8s0t FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of CAK in complex with SY-5609

EMD-19628

Single-particle
2.3 Å
EMD-19628
3D View Gallery
Deposition: 14/02/2024
Map released: 25/12/2024
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: CDK-activating kinase
Fitted models: 8s0t

Deposition Authors: Feng J , Cronin NB , Marineau JJ , Greber BJ
TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network.
Jones T , Feng J , Luyties O , Cozzolino K, Sanford L, Rimel JK, Ebmeier CC , Shelby GS, Watts LP , Rodino J , Rajagopal N, Hu S, Brennan F , Maas ZL , Alnemy S, Richter WF , Koh AF , Cronin NB , Madduri A , Das J, Cooper E, Hamman KB , Carulli JP , Allen MA , Spencer S , Kotecha A , Marineau JJ , Greber BJ , Dowell RD , Taatjes DJ
(2025) Sci Adv , 11 , eadr9660 - eadr9660
PUBMED: 40020069
DOI: doi:10.1126/sciadv.adr9660
ISSN: 2375-2548
Grant Support: