EMD-19620
H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex
EMD-19620
Single-particle3.6 Å
Deposition: 13/02/2024Map released: 02/10/2024
Last modified: 25/12/2024
Sample Organism:
Homo sapiens,
synthetic construct
Sample: H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex
Fitted models: 8s0b
Deposition Authors: Greiwe JF
,
Weissmann F ,
Diffley JFX ,
Costa A
Sample: H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex
Fitted models: 8s0b
Deposition Authors: Greiwe JF
,
Weissmann F ,
Diffley JFX ,
Costa A
MCM double hexamer loading visualized with human proteins.
Weissmann F ,
Greiwe JF ,
Puhringer T ,
Eastwood EL ,
Couves EC ,
Miller TCR ,
Diffley JFX ,
Costa A
(2024) Nature , 636 , 499 - 508
,
Greiwe JF ,
Puhringer T ,
Eastwood EL ,
Couves EC ,
Miller TCR ,
Diffley JFX ,
Costa A
(2024) Nature , 636 , 499 - 508
Secondary citations:
- Weissmann F, Greiwe JF, Puhringer T, Miller TCR, Diffley JFX & Costa A. (2024) MCM Double Hexamer Loading Visualised with Human Proteins. bioRxiv,
- Liebschner D, Afonine PV, Baker ML, Bunkoczi G, Chen VB, Croll TI, Hintze B, Hung LW, Jain S, McCoy AJ, Moriarty NW, Oeffner RD, Poon BK, Prisant MG, Read RJ, Richardson JS, Richardson DC, Sammito MD, Sobolev OV, Stockwell DH, Terwilliger TC, Urzhumtsev AG, Videau LL, Williams CJ & Adams PD. (2019) Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix. Acta Crystallogr D Struct Biol, 75, 861 - 877
Grant Support:
- The Francis Crick Institute: CC2002, CC2009 (United Kingdom)
- European Research Council (ERC): 820102 (European Union)
- Wellcome Trust: 219527/Z/19/Z (United Kingdom)
- European Research Council (ERC): 101020432-MeChroRep (European Union)