EMD-19605
(CAG)2 DNA-bound MutSbeta in open form with kinked MSH2 clamp
EMD-19605
Single-particle3.37 Å
Deposition: 12/02/2024Map released: 13/11/2024
Last modified: 27/05/2026
Sample Organism:
Homo sapiens
Sample: MutSbeta-DNA-ADP complex
Fitted models: 8rz7
Deposition Authors: Lee J-H, Thomsen M
,
Daub H,
Steinbacher S,
Sztyler A,
Thieulin-Pardo G,
Neudegger T,
Plotnikov N,
Iyer RR,
Wilkinson H,
Monteagudo E,
Felsenfeld DP,
Haque T,
Finley M,
Dominguez C,
Vogt TF,
Prasad BC
Sample: MutSbeta-DNA-ADP complex
Fitted models: 8rz7
Deposition Authors: Lee J-H, Thomsen M
,
Daub H,
Steinbacher S,
Sztyler A,
Thieulin-Pardo G,
Neudegger T,
Plotnikov N,
Iyer RR,
Wilkinson H,
Monteagudo E,
Felsenfeld DP,
Haque T,
Finley M,
Dominguez C,
Vogt TF,
Prasad BC
Elucidation of multiple high-resolution states of human MutS beta by cryo-EM reveals interplay between ATP/ADP binding and heteroduplex DNA recognition.
Lee JH,
Thomsen M ,
Daub H,
Thieulin-Pardo G,
Steinbacher S,
Sztyler A,
Dahiya V,
Neudegger T,
Dominguez C,
Iyer RR,
Wilkinson HA,
Monteagudo E,
Plotnikov NV,
Felsenfeld DP,
Haque TS,
Finley M,
Boudet J,
Vogt TF,
Prasad BC
(2025) Nucleic Acids Res , 53
,
Daub H,
Thieulin-Pardo G,
Steinbacher S,
Sztyler A,
Dahiya V,
Neudegger T,
Dominguez C,
Iyer RR,
Wilkinson HA,
Monteagudo E,
Plotnikov NV,
Felsenfeld DP,
Haque TS,
Finley M,
Boudet J,
Vogt TF,
Prasad BC
(2025) Nucleic Acids Res , 53
Grant Support:
- CHDI Foundation: (United States)