EMD-19495

Single-particle
3.73 Å
EMD-19495
3D View Gallery
Deposition: 29/01/2024
Map released: 13/11/2024
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19495

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8rts summary report (pdf.gz) Map-8rts FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of a homomeric human LRRC8C Volume-Regulated Anion Channel

EMD-19495

Single-particle
3.73 Å
EMD-19495
3D View Gallery
Deposition: 29/01/2024
Map released: 13/11/2024
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Homomeric human LRRC8C Volume-Regulated Anion Channel
Fitted models: 8rts

Deposition Authors: Rutz S, Quinodoz M , Peter V , Garavelli L, Innes M, Kellenberger S , Barone A, Campos-Xavier B , Unger S, Rivolta C , Dutzler R , Superti-Furga A
De novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder.
Quinodoz M , Rutz S, Peter V , Garavelli L, Innes AM , Lehmann EF , Kellenberger S , Peng Z, Barone A, Campos-Xavier B , Unger S, Rivolta C , Dutzler R , Superti-Furga A
(2025) EMBO J , 44 , 413 - 436
PUBMED: 39623139
DOI: doi:10.1038/s44318-024-00322-y
ISSN: 1460-2075
ASTM: EMJODG