Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-19495
Structure of a homomeric human LRRC8C Volume-Regulated Anion Channel
EMD-19495
Single-particle3.73 Å
Deposition: 29/01/2024Map released: 13/11/2024
Last modified: 04/06/2025
Sample Organism:
Homo sapiens
Sample: Homomeric human LRRC8C Volume-Regulated Anion Channel
Fitted models: 8rts
Deposition Authors: Rutz S, Quinodoz M
,
Peter V ,
Garavelli L,
Innes M,
Kellenberger S ,
Barone A,
Campos-Xavier B ,
Unger S,
Rivolta C ,
Dutzler R ,
Superti-Furga A
Sample: Homomeric human LRRC8C Volume-Regulated Anion Channel
Fitted models: 8rts
Deposition Authors: Rutz S, Quinodoz M
,
Peter V ,
Garavelli L,
Innes M,
Kellenberger S ,
Barone A,
Campos-Xavier B ,
Unger S,
Rivolta C ,
Dutzler R ,
Superti-Furga A
De novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder.
Quinodoz M ,
Rutz S,
Peter V ,
Garavelli L,
Innes AM ,
Lehmann EF ,
Kellenberger S ,
Peng Z,
Barone A,
Campos-Xavier B ,
Unger S,
Rivolta C ,
Dutzler R ,
Superti-Furga A
(2025) EMBO J , 44 , 413 - 436
,
Rutz S,
Peter V ,
Garavelli L,
Innes AM ,
Lehmann EF ,
Kellenberger S ,
Peng Z,
Barone A,
Campos-Xavier B ,
Unger S,
Rivolta C ,
Dutzler R ,
Superti-Furga A
(2025) EMBO J , 44 , 413 - 436
Grant Support:
- Swiss National Science Foundation: No. 310030_204373 (Switzerland)