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EMD-19407
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24
EMD-19407
Single-particle3.1 Å
Deposition: 12/01/2024Map released: 03/04/2024
Last modified: 23/10/2024
Sample Organism:
Homo sapiens
Sample: Complex of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24
Fitted models: 8roy
Deposition Authors: Shilliday F
,
Lucas SCC ,
Richter M,
Michaelides IN ,
Fusani L
Sample: Complex of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24
Fitted models: 8roy
Deposition Authors: Shilliday F
,
Lucas SCC ,
Richter M,
Michaelides IN ,
Fusani L
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.
Lucas SCC ,
Ahmed A,
Ashraf SN,
Argyrou A ,
Bauer MR ,
De Donatis GM,
Demanze S ,
Eisele F ,
Fusani L,
Hock A,
Kadamur G ,
Li S,
Macmillan-Jones A ,
Michaelides IN ,
Phillips C,
Rehnstrom M,
Richter M,
Rodrigo-Brenni MC ,
Shilliday F ,
Wang P,
Storer RI
(2024) J Med Chem , 67 , 5538 - 5566
,
Ahmed A,
Ashraf SN,
Argyrou A ,
Bauer MR ,
De Donatis GM,
Demanze S ,
Eisele F ,
Fusani L,
Hock A,
Kadamur G ,
Li S,
Macmillan-Jones A ,
Michaelides IN ,
Phillips C,
Rehnstrom M,
Richter M,
Rodrigo-Brenni MC ,
Shilliday F ,
Wang P,
Storer RI
(2024) J Med Chem , 67 , 5538 - 5566
Grant Support: