EMD-19406

Single-particle
3.3 Å
EMD-19406
3D View Gallery
Deposition: 12/01/2024
Map released: 03/04/2024
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19406

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8rox summary report (pdf.gz) Map-8rox FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12

EMD-19406

Single-particle
3.3 Å
EMD-19406
3D View Gallery
Deposition: 12/01/2024
Map released: 03/04/2024
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24
Fitted models: 8rox

Deposition Authors: Shilliday F , Lucas SCC , Richter M, Michaelides IN , Fusani L
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.
Lucas SCC , Ahmed A, Ashraf SN, Argyrou A , Bauer MR , De Donatis GM, Demanze S , Eisele F , Fusani L, Hock A, Kadamur G , Li S, Macmillan-Jones A , Michaelides IN , Phillips C, Rehnstrom M, Richter M, Rodrigo-Brenni MC , Shilliday F , Wang P, Storer RI
(2024) J Med Chem , 67 , 5538 - 5566
PUBMED: 38513086
DOI: doi:10.1021/acs.jmedchem.3c02136
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: