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EMD-19066
TREK2 in OGNG/CHS detergent micelle with biparatopic inhibitory nanobody Nb6158
EMD-19066
Single-particle7.37 Å
Deposition: 07/12/2023Map released: 29/05/2024
Last modified: 29/05/2024
Sample Organism:
Homo sapiens,
Lama glama
Sample: Complex of TREK2 and inhibitory nanobody Nb6158
Deposition Authors: Smith KHM
,
Tucker SJ
Sample: Complex of TREK2 and inhibitory nanobody Nb6158
Deposition Authors: Smith KHM
,
Tucker SJ
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Rodstrom KEJ,
Cloake A,
Sormann J ,
Baronina A,
Smith KHM ,
Pike ACW ,
Ang J,
Proks P,
Schewe M ,
Holland-Kaye I,
Bushell SR,
Elliott J ,
Pardon E ,
Baukrowitz T,
Owens RJ ,
Newstead S,
Steyaert J ,
Carpenter EP,
Tucker SJ
(2024) Nat Commun , 15 , 4173 - 4173
,
Baronina A,
Smith KHM ,
Pike ACW ,
Ang J,
Proks P,
Schewe M ,
Holland-Kaye I,
Bushell SR,
Elliott J ,
Pardon E ,
Baukrowitz T,
Owens RJ ,
Newstead S,
Steyaert J ,
Carpenter EP,
Tucker SJ
(2024) Nat Commun , 15 , 4173 - 4173
Grant Support:
- UK Research and Innovation (UKRI): (United Kingdom)