EMD-18990
CryoEM map of tau PHF sarkosyl-extracted from a human AD patient (associated with in situ tomography)
EMD-18990
Helical reconstruction3.0 Å
Deposition: 27/11/2023Map released: 24/07/2024
Last modified: 07/08/2024
Sample Organism:
Homo sapiens
Sample: tau PHF amyloid fibril
Deposition Authors: Wilkinson MW
,
Gilbert MAG ,
Fatima N,
Jenkins J ,
O'Sullivan TJ,
Schertel A,
Halfon Y,
Morrema THJ,
Geibel M ,
Ranson NA ,
Radford SE ,
Hoozemans JJM ,
Frank RAW
Sample: tau PHF amyloid fibril
Deposition Authors: Wilkinson MW
,
Gilbert MAG ,
Fatima N,
Jenkins J ,
O'Sullivan TJ,
Schertel A,
Halfon Y,
Morrema THJ,
Geibel M ,
Ranson NA ,
Radford SE ,
Hoozemans JJM ,
Frank RAW
CryoET of beta-amyloid and tau within postmortem Alzheimer's disease brain.
Gilbert MAG ,
Fatima N,
Jenkins J ,
O'Sullivan TJ,
Schertel A,
Halfon Y,
Wilkinson M ,
Morrema THJ,
Geibel M ,
Read RJ ,
Ranson NA ,
Radford SE ,
Hoozemans JJM ,
Frank RAW
(2024) Nature , 631 , 913 - 919
,
Fatima N,
Jenkins J ,
O'Sullivan TJ,
Schertel A,
Halfon Y,
Wilkinson M ,
Morrema THJ,
Geibel M ,
Read RJ ,
Ranson NA ,
Radford SE ,
Hoozemans JJM ,
Frank RAW
(2024) Nature , 631 , 913 - 919
Grant Support:
- Medical Research Council (MRC, United Kingdom): MR/T011149/1 (United Kingdom)
- Wellcome Trust: 204963 (United Kingdom)
- UK Research and Innovation (UKRI): MR/V022644/1 (United Kingdom)
- Wellcome Trust: 221524/Z/20/Z (United Kingdom)