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EMD-18778
Structure of DNMT3A1 UDR region bound to H2AK119ub nucleosome
EMD-18778
Single-particle3.1 Å
Deposition: 27/10/2023Map released: 23/10/2024
Last modified: 18/12/2024
Sample Organism:
Homo sapiens,
synthetic construct
Sample: DNMT3A1-DNMT3L in complex with a human H2AKc119ub nucleosome wrapped with 195bp of Widom-601 positioning DNA
Fitted models: 8qzm
Deposition Authors: Wapenaar H
,
Wilson MD
Sample: DNMT3A1-DNMT3L in complex with a human H2AKc119ub nucleosome wrapped with 195bp of Widom-601 positioning DNA
Fitted models: 8qzm
Deposition Authors: Wapenaar H
,
Wilson MD
The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Wapenaar H ,
Clifford G,
Rolls W ,
Pasquier M,
Burdett H,
Zhang Y ,
Deak G,
Zou J ,
Spanos C ,
Taylor MRD,
Mills J ,
Watson JA ,
Kumar D,
Clark R ,
Das A,
Valsakumar D ,
Bramham J,
Voigt P ,
Sproul D ,
Wilson MD
(2024) EMBO Rep , 25 , 5743 - 5779
,
Clifford G,
Rolls W ,
Pasquier M,
Burdett H,
Zhang Y ,
Deak G,
Zou J ,
Spanos C ,
Taylor MRD,
Mills J ,
Watson JA ,
Kumar D,
Clark R ,
Das A,
Valsakumar D ,
Bramham J,
Voigt P ,
Sproul D ,
Wilson MD
(2024) EMBO Rep , 25 , 5743 - 5779
Grant Support:
- Wellcome Trust: 210493/Z/18/Z (United Kingdom)
- Medical Research Council (MRC, United Kingdom): T029471/1 (United Kingdom)