EMD-18694

Single-particle
3.08 Å
EMD-18694
3D View Gallery
Deposition: 19/10/2023
Map released: 02/10/2024
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-18694

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8qwf summary report (pdf.gz) Map-8qwf FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Quaternary complex of ReChb - crRNA - target dsDNA - collateral dsDNA

EMD-18694

Single-particle
3.08 Å
EMD-18694
3D View Gallery
Deposition: 19/10/2023
Map released: 02/10/2024
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: synthetic construct
Sample: Quaternary complex of ReChb - crRNA - target dsDNA - collateral dsDNA
Fitted models: 8qwf

Deposition Authors: Lopez-Alonso JP , Ubarretxena-Belandia I , Tascon I
A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection.
Jabalera Y , Tascon I , Samperio S , Lopez-Alonso JP , Gonzalez-Lopez M, Aransay AM , Abascal-Palacios G , Beisel CL , Ubarretxena-Belandia I , Perez-Jimenez R
(2025) Nat Biotechnol , 43 , 1663 - 1672
PUBMED: 39482449
DOI: doi:10.1038/s41587-024-02461-3
ISSN: 1087-0156
ASTM: NABIF9
Grant Support: