EMD-18668
Structure of human SPNS2 in DDM
EMD-18668
Single-particle3.68 Å
Deposition: 17/10/2023Map released: 19/02/2025
Last modified: 19/02/2025
Sample Organism:
Homo sapiens,
Vicugna pacos
Sample: Complex of SPNS2 with nanobody D12
Fitted models: 8qv6
Deposition Authors: Li HZ, Pike ACW
,
McKinley G,
Mukhopadhyay SMM,
Moreau C,
Scacioc A,
Abrusci P,
Borkowska O,
Chalk R,
Stefanic S ,
Burgess-Brown N,
Duerr KL,
Sauer DB
Sample: Complex of SPNS2 with nanobody D12
Fitted models: 8qv6
Deposition Authors: Li HZ, Pike ACW
,
McKinley G,
Mukhopadhyay SMM,
Moreau C,
Scacioc A,
Abrusci P,
Borkowska O,
Chalk R,
Stefanic S ,
Burgess-Brown N,
Duerr KL,
Sauer DB
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2.
Li HZ,
Pike ACW ,
Chang YN,
Prakaash D,
Gelova Z ,
Stanka J ,
Moreau C,
Scott HC,
Wunder F ,
Wolf G ,
Scacioc A,
McKinley G,
Batoulis H,
Mukhopadhyay S,
Garofoli A,
Pinto-Fernandez A ,
Kessler BM ,
Burgess-Brown NA,
Stefanic S ,
Wiedmer T ,
Durr KL ,
Puetter V,
Ehrmann A,
Khalid S ,
Ingles-Prieto A ,
Superti-Furga G ,
Sauer DB
(2025) Nat Commun , 16 , 721 - 721
,
Chang YN,
Prakaash D,
Gelova Z ,
Stanka J ,
Moreau C,
Scott HC,
Wunder F ,
Wolf G ,
Scacioc A,
McKinley G,
Batoulis H,
Mukhopadhyay S,
Garofoli A,
Pinto-Fernandez A ,
Kessler BM ,
Burgess-Brown NA,
Stefanic S ,
Wiedmer T ,
Durr KL ,
Puetter V,
Ehrmann A,
Khalid S ,
Ingles-Prieto A ,
Superti-Furga G ,
Sauer DB
(2025) Nat Commun , 16 , 721 - 721
Grant Support:
- Innovative Medicines Initiative: 777372 (Switzerland)
- Wellcome Trust: 106169/Z/14/Z (United Kingdom)