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EMD-18660
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5
EMD-18660
Single-particle2.5 Å
Deposition: 16/10/2023Map released: 03/04/2024
Last modified: 03/04/2024
Sample Organism:
Homo sapiens
Sample: Homotetramer of Human Kv3.1a with modulator AUT5
Fitted models: 8qud
Deposition Authors: Chi G
,
Mckinley G,
Marsden B,
Pike ACW,
Ye M,
Brooke LM,
Bakshi S,
Lakshminarayana B,
Pilati N,
Marasco A ,
Gunthorpe M,
Alvaro GS,
Large CH ,
Williams E,
Sauer DB
Sample: Homotetramer of Human Kv3.1a with modulator AUT5
Fitted models: 8qud
Deposition Authors: Chi G
,
Mckinley G,
Marsden B,
Pike ACW,
Ye M,
Brooke LM,
Bakshi S,
Lakshminarayana B,
Pilati N,
Marasco A ,
Gunthorpe M,
Alvaro GS,
Large CH ,
Williams E,
Sauer DB
The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Liang Q ,
Chi G ,
Cirqueira L ,
Zhi L,
Marasco A ,
Pilati N,
Gunthorpe MJ ,
Alvaro G,
Large CH ,
Sauer DB ,
Treptow W ,
Covarrubias M
(2024) Nat Commun , 15 , 2533 - 2533
,
Chi G ,
Cirqueira L ,
Zhi L,
Marasco A ,
Pilati N,
Gunthorpe MJ ,
Alvaro G,
Large CH ,
Sauer DB ,
Treptow W ,
Covarrubias M
(2024) Nat Commun , 15 , 2533 - 2533
Grant Support:
- Wellcome Trust: (United Kingdom)
- Innovative Medicines Initiative: (Switzerland)