EMD-18657
PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1
EMD-18657
Single-particle3.5 Å
Deposition: 14/10/2023Map released: 06/12/2023
Last modified: 02/10/2024
Sample Organism:
Homo sapiens
Sample: KRAS/ACBI3/VHL/EloB/EloC/Cul2/Rbx1
Fitted models: 8qu8
Deposition Authors: Fischer G
,
Peter D ,
Arce-Solano S
Sample: KRAS/ACBI3/VHL/EloB/EloC/Cul2/Rbx1
Fitted models: 8qu8
Deposition Authors: Fischer G
,
Peter D ,
Arce-Solano S
Targeting cancer with small-molecule pan-KRAS degraders.
Popow J ,
Farnaby W ,
Gollner A ,
Kofink C ,
Fischer G ,
Wurm M ,
Zollman D ,
Wijaya A ,
Mischerikow N,
Hasenoehrl C,
Prokofeva P ,
Arnhof H,
Arce-Solano S ,
Bell S,
Boeck G ,
Diers E ,
Frost AB ,
Goodwin-Tindall J,
Karolyi-Oezguer J,
Khan S,
Klawatsch T ,
Koegl M ,
Kousek R,
Kratochvil B,
Kropatsch K,
Lauber AA ,
McLennan R,
Olt S,
Peter D ,
Petermann O,
Roessler V,
Stolt-Bergner P ,
Strack P,
Strauss E,
Trainor N ,
Vetma V ,
Whitworth C ,
Zhong S,
Quant J ,
Weinstabl H ,
Kuster B ,
Ettmayer P ,
Ciulli A
(2024) Science , 385 , 1338 - 1347
,
Farnaby W ,
Gollner A ,
Kofink C ,
Fischer G ,
Wurm M ,
Zollman D ,
Wijaya A ,
Mischerikow N,
Hasenoehrl C,
Prokofeva P ,
Arnhof H,
Arce-Solano S ,
Bell S,
Boeck G ,
Diers E ,
Frost AB ,
Goodwin-Tindall J,
Karolyi-Oezguer J,
Khan S,
Klawatsch T ,
Koegl M ,
Kousek R,
Kratochvil B,
Kropatsch K,
Lauber AA ,
McLennan R,
Olt S,
Peter D ,
Petermann O,
Roessler V,
Stolt-Bergner P ,
Strack P,
Strauss E,
Trainor N ,
Vetma V ,
Whitworth C ,
Zhong S,
Quant J ,
Weinstabl H ,
Kuster B ,
Ettmayer P ,
Ciulli A
(2024) Science , 385 , 1338 - 1347
Grant Support:
- Other private: Boehringer Ingelheim (Austria)