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EMD-18649
Local refinement of SARS-CoV-2 BA.2.86 Spike and XBB-7 Fab
EMD-18649
Single-particle3.6 Å
Deposition: 12/10/2023Map released: 08/05/2024
Last modified: 06/11/2024
Sample Organism:
Homo sapiens,
Severe acute respiratory syndrome coronavirus 2
Sample: BA-2.86 variant SARS-CoV2 S protein complexed with XBB-7 fab.
Fitted models: 8qtd
Deposition Authors: Ren J, Duyvesteyn HME, Stuart DI
Sample: BA-2.86 variant SARS-CoV2 S protein complexed with XBB-7 fab.
Fitted models: 8qtd
Deposition Authors: Ren J, Duyvesteyn HME, Stuart DI
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Liu C,
Zhou D 
,
Dijokaite-Guraliuc A ,
Supasa P,
Duyvesteyn HME,
Ginn HM,
Selvaraj M,
Mentzer AJ ,
Das R,
de Silva TI,
Ritter TG,
Plowright M,
Newman TAH ,
Stafford L,
Kronsteiner B,
Temperton N ,
Lui Y,
Fellermeyer M,
Goulder P,
Klenerman P,
Dunachie SJ,
Barton MI,
Kutuzov MA,
Dushek O,
Fry EE,
Mongkolsapaya J,
Ren J,
Stuart DI,
Screaton GR
(2024) Cell Rep Med , 5 , 101553 - 101553
,
Dijokaite-Guraliuc A ,
Supasa P,
Duyvesteyn HME,
Ginn HM,
Selvaraj M,
Mentzer AJ ,
Das R,
de Silva TI,
Ritter TG,
Plowright M,
Newman TAH ,
Stafford L,
Kronsteiner B,
Temperton N ,
Lui Y,
Fellermeyer M,
Goulder P,
Klenerman P,
Dunachie SJ,
Barton MI,
Kutuzov MA,
Dushek O,
Fry EE,
Mongkolsapaya J,
Ren J,
Stuart DI,
Screaton GR
(2024) Cell Rep Med , 5 , 101553 - 101553
Grant Support:
- CAMS Innovation Fund for Medical Sciences (CIFMS): 2018-I2M-2-002 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MR/N00065X/1 (United Kingdom)